arXiv preprints from January 1, 2026 through September 20, 2026 — 16:00:22 EST
Privacy-preserving model co-training in medical research is often hindered by server-dependent architectures incompatible with protected hospital data systems and by the predominant focus on relative effect measures (hazard ratios) which lack clinical interpretability for absolute survival risk assessment. We propose FedRD, a...
The U.S. Food and Drug Administration (FDA) released a landmark draft guidance in January 2026 on the use of Bayesian methodology to support primary inference in clinical trials of drugs and biological products. For sponsors, the central message is not merely that ``Bayes is allowed,'' but that Bayesian designs should be justified...
Reinforcement learning (RL) has achieved remarkable success in real-world decision-making across diverse domains, including gaming, robotics, online advertising, public health, and natural language processing. Despite these advances, a substantial gap remains between RL research and its deployment in many practical settings. Two...
This paper presents a semi-supervised learning framework for Gaussian mixture modelling under a Missing at Random (MAR) mechanism. The method explicitly parameterizes the missingness mechanism by modelling the probability of missingness as a function of classification uncertainty. To quantify classification uncertainty, we introduce...
This guide based on recent papers should help researchers avoid some of the most common pitfalls of missing value imputation imputation.
Small area estimation (SAE) plays a central role in survey statistics and epidemiology, providing reliable estimates for domains with limited sample sizes. The multivariate Fay-Herriot model has been extensively used for this purpose, because it enhances estimation accuracy by borrowing strength across multiple correlated variables....
This article surveys recent progress in the Bradley-Terry (BT) model and its extensions. We focus on the statistical and computational aspects, with emphasis on the regime in which both the number of objects and the volume of comparisons tend to infinity, a setting relevant to large-scale applications. The main topics include...
Clustering multivariate data is a pervasive task in many applied problems, particularly in social studies and life science. Model-based approaches to clustering rely on mixture models, where each mixture component corresponds to the kernel of a distribution characterizing a latent sub-group. Current methods developed within this...
Species distribution models (SDMs) are widely used to assess the effects of environmental factors on species distributions. However, classical SDMs ignore inter-species dependencies. Multivariate SDMs (MSDMs), especially those based on latent Gaussian fields such as the multivariate Poisson log-normal (MPLN), address this limitation...
Classical geostatistics encodes spatial dependence by prescribing variograms or covariance kernels on Euclidean domains, whereas the SPDE--GMRF paradigm specifies Gaussian fields through an elliptic precision operator whose inverse is the corresponding Green operator. We develop an operator-based formulation of Gaussian spatial random...
Estimating Heterogeneous Treatment Effects (HTE) in industrial applications such as AdTech and healthcare presents a dual challenge: extreme class imbalance and heavy-tailed outcome distributions. While the X-Learner framework effectively addresses imbalance through cross-imputation, we demonstrate that it is fundamentally vulnerable...
Functional bilevel optimization (FBO) provides a powerful framework for hierarchical learning in function spaces, yet current methods are limited to static offline settings and perform suboptimally in online, non-stationary scenarios. We propose SmoothFBO, the first algorithm for non-stationary FBO with both theoretical guarantees and...
We study in-context learning for nonparametric regression with $α$-Hölder smooth regression functions, for some $α>0$. We prove that, with $n$ in-context examples and $d$-dimensional regression covariates, a pretrained transformer with $Θ(\log n)$ parameters and $Ω\bigl(n^{2α/(2α+d)}\log^3 n\bigr)$ pretraining sequences can achieve...
We study various types of consistency of honest decision trees and random forests in the regression setting. In contrast to related literature, our proofs are elementary and follow the classical arguments used for smoothing methods. Under mild regularity conditions on the regression function and data distribution, we establish weak...
Bayesian model comparison implements Occam's razor through its sensitivity to the prior. However, prior-dependence makes it important to assess the influence of plausible alternative priors. Such prior sensitivity analyses for the Bayesian evidence are expensive, either requiring repeated, costly model re-fits or specialised sampling...
We study the problem of estimating causal effects under hidden confounding in the following unpaired data setting: we observe some covariates $X$ and an outcome $Y$ under different experimental conditions (environments) but do not observe them jointly; we either observe $X$ or $Y$. Under appropriate regularity conditions, the problem...
Principal component analysis (PCA) is a tool to capture factors that explain variation in data. Across domains, data are now collected across multiple contexts (for example, individuals with different diseases, cells of different types, or words across texts). While the factors explaining variation in data are undoubtedly shared...
Weighting methods are essential tools for estimating causal effects in observational studies, with the goal of balancing pre-treatment covariates across treatment groups. Traditional approaches pursue this objective indirectly, for example, via inverse propensity score weighting or by matching a finite number of covariate moments, and...
Macroeconomic conditions influence the environments in which health systems operate, yet their value as leading signals of health system capacity has not been systematically evaluated. In this study, we examine whether selected macroeconomic indicators contain predictive information for several capacity-related public health targets,...
In recent years, Rectified flow (RF) has gained considerable popularity largely due to its generation efficiency and state-of-the-art performance. In this paper, we investigate the degree to which RF automatically adapts to the intrinsic low dimensionality of the support of the target distribution to accelerate sampling. We show that,...
Current alignment-based methods for classification in geometric morphometrics do not generally address the classification of new individuals that were not part of the study sample. However, in the context of infant and child nutritional assessment from body shape images this is a relevant problem. In this setting, classification rules...
Two broad positions within statistics define a treatment effect, on the one hand, as a parameter of a statistical model, and on the other, as an appropriate population-level difference in outcomes or counterfactual outcomes under the different treatment regimes. This short expository paper presents some simple but consequential...
The growing availability of large health databases has expanded the use of observational studies for comparative effectiveness research. Unlike randomized trials, observational studies must adjust for systematic differences in patient characteristics between treatment groups. Propensity score methods, including matching, weighting,...
This paper introduces a new problem-dependent regret measure for online convex optimization with smooth losses. The notion, which we call the $G^\star$ regret, depends on the cumulative squared gradient norm evaluated at the decision in hindsight. We show that the $G^\star$ regret strictly refines the existing $L^\star$ (small loss)...
We consider inference for M-estimators after model selection using a sparsity-inducing penalty. While existing methods for this task require bespoke inference procedures, we propose a simpler approach, which relies on two insights: (i) adding and subtracting carefully-constructed noise to a Gaussian random variable with unknown mean...