arXiv preprints from January 1, 2026 through July 20, 2026 — 00:47:44 EST
Accurate quantification of local strain fields during bladder contraction is essential for understanding the biomechanics of bladder micturition, in both health and disease. Conventional digital image correlation (DIC) methods have been successfully applied to various biological tissues; however, this approach requires artificial...
The detection of rare cell types in single-cell transcriptomics data is crucial for elucidating disease pathogenesis and tissue development dynamics. However, a critical gap that persists in current methods is their inability to provide an explanation based on genes for each cell they have detected as rare. We identify three primary...
Accurate identification of cancer driver genes from passenger mutations is essential for understanding tumorigenesis and clinical translation. We present HyperNetWalk, an unsupervised framework that unifies personalized and cohort-level driver gene identification within a shared inference architecture. HyperNetWalk builds a layered...
The vertebrate motor system employs dimensionality-reducing strategies to limit the complexity of movement coordination, for efficient motor control. But when environments are dense with hidden action-outcome contingencies, movement complexity can promote behavioral innovation. Humans, perhaps uniquely, may infer the presence of...
We study a well mixed SIR epidemic model with heterogeneous susceptibility and infectivity, allowing for an arbitrary joint distribution of these traits. Using an exact final size formulation and a branching process approximation for early epidemic dynamics, we show that both the final epidemic size and the probability of a major...
Ficus maxima (Moraceae, subgenus Pharmacosycea), known in Brazil as "caxinguba", occurs in northern Brazil and in Mato Grosso. Its leaves and fruits are important food sources for birds and mammals, and the species is traditionally used by Indigenous peoples of Central and South America to treat intestinal parasites, gingivitis,...
Background: Understanding electronic interactions in protein active sites is fundamental to drug discovery and enzyme engineering, but remains computationally challenging due to exponential scaling of quantum mechanical calculations. Results: We present a quantum-classical hybrid framework for simulating protein fragment electronic...
We have previously shown that Good-Turing statistics can be applied to molecular dynamics trajectories to estimate the probability of observing completely new (thus far unobserved) biomolecular structures, and showed that the method is stable, dependable and its predictions verifiable. The major problem with that initial algorithm was...
Background: Accurate week-ahead forecasts of continuous glucose monitoring (CGM) derived metrics could enable proactive diabetes management, but relative performance of modern tabular learning approaches is incompletely defined. Methods: We trained and internally validated four regression models (CatBoost, XGBoost, AutoGluon,...
Aim/background: Continuous glucose monitoring (CGM) generates dense time-series data, posing challenges for efficient storage, transmission, and analysis. This study evaluates novel encoding strategies that reduce CGM profiles to a compact set of landmark points while maintaining fidelity in reconstructed signals and derived glycemic...
The outbreak of mutant strains and vaccination behaviors have been the focus of recent epidemiological research, but most existing epidemic models failed to simultaneously capture viral mutation and consider the complexity and behavioral dynamics of vaccination. To address this gap, we develop an extended SIRS model that distinguishes...
Liquid chromatography mass spectrometry (LC-MS)-based metabolomics and exposomics aim to measure detectable small molecules in biological samples. The results facilitate hypothesis-generating discovery of metabolic changes and disease mechanisms and provide information about environmental exposures and their effects on human health....
Krotov and Hopfield (2021) proposed a biologically plausible two-layer associative memory network with memory storage capacity exponential in the number of visible neurons. However, the capacity was only linear in the number of hidden neurons. This limitation arose from the choice of nonlinearity between the visible and hidden units,...
Serine hydroxymethyltransferase is an essential enzyme in the Escherichia coli folate pathway, yet it has not been adopted as an antibacterial target, unlike DHFR, DHPS, or thymidylate synthase. To investigate this discrepancy, we applied a multi-scale computational framework that integrates large-scale sequence analysis of 1000...
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive decline and widespread epigenetic dysregulation in the brain. DNA methylation, as a stable yet dynamic epigenetic modification, holds promise as a noninvasive biomarker for early AD detection. However, methylation signatures...
Single-cell data analysis has the potential to revolutionize personalized medicine by characterizing disease-associated molecular changes at the single-cell level. Advanced single-cell multimodal assays can now simultaneously measure various molecules (e.g., DNA, RNA, Protein) across hundreds of thousands of individual cells,...
Many agent-based mathematical models of cranial neural crest cell (CNCC) migration impose a binary phenotypic partition of cells into either leaders or followers. In such models, the movement of leader cells at the front of collectives is guided by local chemoattractant gradients, while follower cells behind leaders move according to...
Many of the most consequential dynamics in human cognition occur \emph{before} events become explicit: before decisions are finalized, emotions are labeled, or meanings stabilize into narrative form. These pre-event states are characterized by ambiguity, contextual tension, and competing latent interpretations. Rogue Variable Theory...