arXiv preprints from January 1, 2026 through July 20, 2026 — 17:38:31 EST
Biomolecular condensates are commonly organized by a small number of scaffold molecules that drive phase separation together with client molecules that do not condense on their own but become selectively recruited into the dense phase. A central open question is how client recruitment feeds back on scaffold interactions to determine...
Accurate segmentation of brain tumors is essential for clinical diagnosis and treatment planning. Deep learning is currently the state-of-the-art for brain tumor segmentation, yet it requires either large datasets or extensive computational resources that are inaccessible in most areas. This makes the problem increasingly difficult:...
The presence of correlated noise, arising from a mixture of independent fluctuations and a common noisy input shared across the neural population, is a ubiquitous feature of neural circuits, yet its impact on collective network dynamics remains poorly understood. We analyze a network of quadratic integrate-and-fire neurons driven by...
Although most theories posit that natural behavior can be explained as maximizing some form of extrinsic reward, often called utility, some behaviors appear to be reward independent. For instance, spontaneous motor babbling in human newborns and curiosity in little kids and other animals seem to elude a simple explanation in terms of...
Recent high-precision experimental confirmations of quantum complementarity have revitalized foundational debates about measurement, description, and realism. This article argues that complementarity is most productively interpreted as an epistemic principle--constraining what can be simultaneously accessed and represented--rather...
Learning, inference, memory, and emergence in biological and artificial systems are often described using disparate theoretical frameworks. Here we develop a cognitive field theory in which cognition is described as a collective nonequilibrium phenomenon governed by the geometry and collective spectrum of a learned cognitive manifold....
Atrial fibrillation (AF) is a common cardiac arrhythmia that significantly increases the risk of stroke and heart failure, necessitating reliable and generalizable detection methods from electrocardiogram (ECG) recordings. Although deep learning has advanced automated AF diagnosis, existing approaches often struggle to exploit...
Recruitment dynamics, or the distribution of the number of offspring among individuals, is central for understanding ecology and evolution. Sweepstakes reproduction (heavy right-tailed offspring number distribution) is central for understanding the ecology and evolution of highly fecund natural populations. Sweepstakes reproduction...
Why do neurons encode information the way they do? Normative answers to this question model neural activity as the solution to an optimisation problem; for example, the celebrated efficient coding hypothesis frames neural activity as the optimal encoding of information under efficiency constraints. Successful normative theories have...
We present a mathematical model that describes the synergistic mechanism of combined Vesicular Stomatitis Virus (VSV) and Vaccinia Virus (VV). The model captures the dynamic interplay between tumor cells, viral replication, and the interferon-mediated immune response, revealing a `ping-pong' synergy where VV-infected cells produce...
Short-term synaptic plasticity (STP) is often regarded as a presynaptic filter of spikes, independent of postsynaptic activity. Recent experiments, however, indicate an associative STP that depends on pre- and postsynaptic coactivation. We develop a normative, information-theoretic theory of associative STP. Extending...
Acute stress alters cognitive performance, yet competing models make divergent predictions regarding the mechanisms, scope, and temporal dynamics of these effects. This large-scale randomized controlled trial tested predications from three influential stress-effect models using a broad cognitive task battery embedded within a...
Introduction Sporadic Creutzfeldt Jakob disease sCJD is a rapidly progressive neurodegenerative disease without effective treatment that usually results in death within one year. The recently applied methods have improved the accuracy of the disease diagnosis and the specific radiological findings provide the necessary information for...
AI agents are increasingly used in long, multi-turn workflows in both research and enterprise settings. As interactions grow, agent behavior often degrades due to loss of constraint focus, error accumulation, and memory-induced drift. This problem is especially visible in real-world deployments where context evolves, distractions are...
Rhizomes play fundamental roles in plant evolution, persistence, and environmental adaptation by enabling clonal propagation, resource storage, and stress resilience. Despite their ecological and agronomic importance across diverse plant lineages, the genetic and developmental regulation of rhizomes remains poorly characterized. Here,...
Batch effects represent a major confounder in genomic diagnostics. In copy number variant (CNV) detection from NGS, many algorithms compare read depth between test samples and a reference sample, assuming they are process-matched. When this assumption is violated, with causes ranging from reagent lot changes to multi-site processing,...
Cerebellar-like networks, in which input activity patterns are separated by projection to a much higher-dimensional space before classification, are a recurring neurobiological motif, present in the cerebellum, dentate gyrus, insect olfactory system, and electrosensory system of the electric fish. Their relatively well-understood...
Malignant tumors exhibit complex pathogenesis, yet classical oncological theories remain fragmented, failing to provide a unifying framework to address this complexity. This gap limits the utility and translational potential of the prevailing "confront-and-eradicate" therapeutic paradigm, constraining transformative therapeutic...
There is little debate about the importance of the ancestral recombination graph in population genetics. An important theoretical tool, the main obstacle to its widespread usage is the computational cost required to match the ever-increasing scale of the data being analyzed. Many of these difficulties have been overcome in the past...
The Moran process is a foundational model of genetic drift and mutation in finite populations. In its standard two-allele form with population size $n$, allele counts, and hence allele frequencies, change through stochastic replacement and mutation, yet converge to a stationary distribution. This distribution undergoes a qualitative...
Tuberculosis (TB) is an airborne disease caused by the pathogen Mycobacterium tuberculosis. In 2023, it returned to being the leading cause of death from an infectious agent globally, replacing COVID-19; in the nineteenth century, one in seven of all humans died of tuberculosis. More than 10 million people are diagnosed with TB every...
Biological memory solves a problem that eludes current AI: storing specific episodic facts without corrupting general semantic knowledge. Complementary Learning Systems theory explains this through two subsystems - a fast hippocampal system using sparse, pattern-separated representations for episodes, and a slow neocortical system...
Neuropixels probes, initially developed for use in small animal models, have transformed basic neuroscience by enabling high-density, single-cell resolution recordings across multiple brain regions simultaneously. The recent development of Neuropixels 1.0 NHP Long, a longer probe designed for non-human primates, has expanded this...
Dietary flavonoids associate with disease prevention in epidemiological studies, yet their polypharmacological mechanisms remain unclear. We establish network pharmacology as a systematic framework to characterize flavonoid therapeutic properties through integrated computational, experimental, and epidemiological validation. We...
Selective attention can momentarily alter visual appearance, but can such effects be learned? We tested whether training attention under sensory competition produces lasting changes in perceived contrast. Across seven days, participants trained on an orientation task with a fixed target location, with or without a salient distractor....