arXiv preprints from January 1, 2026 through September 19, 2026 — 11:18:33 EST
Some aspects of AI development resemble a population process in which models are specialised, retrained on the output of peers, or combined by averaging weights. These practices lead to generations of models, in the biological sense studied by population genetics. Here, I develop this parallelism and interpret multigenerational model...
More than 300 million people worldwide are affected by one of over 7,000 known rare diseases, yet diagnosis remains difficult because patients initially present with incomplete and heterogeneous phenotypes. We present HPOQuest, a training-free framework for sequential phenotype acquisition in rare-disease diagnosis. Starting from a...
Mapping sequencing reads to a reference genome requires preprocessing and alignment choices that can vary with library type, fragment length, sequencing platform, and reference genome. These considerations are particularly important for ancient and historical DNA, where short and damaged fragments can make the most appropriate mapping...
Time-dependent coherent control can enhance excitation transport in open quantum networks, but independently controlling every inter-site coupling creates a control space of high dimension and leads to difficult optimization problems. We introduce an edge-ranking strategy based on the control-induced change in the gradient component...
The brain needs an accurate internal model of the world to generate predictions and guide behavior. However, it must estimate the statistical structure of the environment from limited experience. This is particularly difficult for rare events, whose observed frequencies in a limited sample may substantially under- or overestimate...
Multiparameter flow cytometry generates high-dimensional, unordered single-cell mea- surement data for disease diagnosis and monitoring, yet analysis often remains dependent on manual gating, limiting scalability and reproducibility. Existing machine-learning ap- proaches can reduce annotation burden but frequently require large...
The manifold hypothesis suggests a natural criterion for clustering: partition data according to the manifold component from which each point is drawn. Whether two components are separable depends on a geometric tradeoff: the ambient separation between components versus the largest gap in sampling. In practice, this tradeoff is rarely...
Epigenetic clocks estimate age and aging-related phenotypes from DNA methylation at selected CpG sites, but the extent to which these inputs are influenced by germline genetic variation is unclear. Because methylation at many CpGs is genetically regulated, some between-person variation in clock estimates may reflect inherited genetic...
AI and large language models can recover clinically meaningful features from electronic health records (EHRs), but predictive usefulness does not establish admissibility for causal inference. We introduce information set emulation: an AI typed lift attaches source evidence, clinical and recording times, decision-time availability,...
Lipid nanoparticles (LNPs) have transformed RNA medicine, yet their clinical utility remains constrained by predominant hepatic accumulation after systemic administration. Redirecting LNPs to extrahepatic tissues requires understanding of how lipid chemistry and formulation composition jointly govern in vivo biodistribution. Here, we...
Population-level heterogeneities, combined with temporal fluctuations in sexual partnerships, shape the structure of sexual contact networks and can substantially influence the spread of sexually transmitted infections (STIs). Traditional static network models, which assume fixed attributes of partnerships, such as count and duration,...
Whole genome sequencing (WGS) is essential for precision oncology, yet its clinical adoption remains limited by prohibitive computational costs and multi-day turnaround times. This work presents a fully localized low-resource framework enabling stable deployment of a trillion-parameter biomedical LLM on a single consumer-grade RTX...
Automated execution algorithms are organized into schedule-based and liquidity-seeking families. This paper concerns the first, whose members -- Time-Weighted Average Price (TWAP), Volume-Weighted Average Price (VWAP), Percentage of Volume (POV) and Implementation Shortfall -- are all model-based: each derives its decisions from an...
Alòs, Gatheral and Radoičić derived the Bergomi-Guyon expansion of the implied variance smile from the forest expansion of the cumulant generating function. Its coefficients are sums of products of diamond trees, with prefactors that are polynomials in the log-strike $k$. Matching moments order by order produces, at order $ε^\ell$,...
We present SAiFE_gym, a Python module that provides a collection of simulation environments for studying trading problems in Constant Product Markets (CPMs) with Concentrated Liquidity (CL). These markets give Liquidity Providers (LPs) granular control over how their capital is allocated and enable them to adjust their range of...
Kalshi's multivariate-event architecture produces market objects on demand from exact selected legs. Across a registered seven-day interval, 190 independently validated temporal shards yield 7,611,594 unique REST MVE market tickers after excluding 5,777 boundary-overlap observations; the population was created at an average rate of...
We study libraries of cross-sectional signals: at each date, a forecast vector over $d$ assets intended to predict the next period's cross-sectional return. Demeaned and unit-normalized, a signal is a point on a sphere and its $T$-date history a point on a product of $T$ spheres. A pairwise correlation cap on histories is a minimum...
The reuse of metal powders in directed energy deposition using laser powder offers promising sustainability benefits for additive manufacturing, yet its impact on part quality remains unknown. This study investigates the influence of powder reuse on the directed energy deposition process of Inconel 625. Virgin powder was first...
We study the canonical \textsf{Maximum Clique} and \textsf{Maximum Independent Set} problems in the one-pass edge-arrival graph streaming setting. Here, the edges of some input graph $G = (V,E)$ are presented one at a time (possibly including deletions), before an algorithm needs to produce either a large clique or independent set at...
Video streaming dominates global internet traffic, yet conventional pipelines remain inefficient for structured, human-centric content such as sports, performance, or interactive media. Standard codecs re-encode entire frames, foreground and background alike, treating all pixels uniformly and ignoring the semantic structure of the...
Cloud-native microservices architectures rely on network namespaces for isolation, with the overhead of container communications remaining a critical performance bottleneck. While colocating containers on the same host mitigates some of this overhead, it cannot match the performance of communication within a single network namespace....
Multi-modal talking avatar synthesis aims to generate realistic talking videos from a reference portrait and speech. Despite rapid progress in diffusion-based methods, existing approaches still struggle to jointly achieve accurate lip articulation, human-preferred motion aesthetics, and efficient inference. We observe that phonetic...
Visual-inertial odometry (VIO) is a core capability for autonomous operation in GPS-denied subterranean environments, yet its reliability can degrade sharply under sensor drift, calibration errors, and dynamic occlusion. Existing evaluations mainly emphasize nominal-condition accuracy, offering limited insight into when practical...
3D Gaussian Splatting (3DGS) enables photorealistic novel view synthesis, but transmitting gigabyte-scale scene data remains challenging for immersive applications. Traditional HTTP Adaptive Streaming over TCP introduces Head-of-Line (HOL) blocking and coarse segmenting ill-suited to fine-grained 3DGS delivery. We propose MoQSplat,...
State-of-the-art vision-language-action models (VLA) for autonomous driving face critical limitations: excessive parameter counts, inefficient high-resolution image processing, and lack of temporal memory. We introduce Fast and EffectIVE VLA (FIVE-VLA) to address these through two key contributions. First, we employ an efficient...